This has been a fantastic thread to read!!! Thank you, everyone. I'm glad to see non-fantasy games being run and I especially like seeing the suggestions come in for making CL friendlier to non-fantasy genres.
I also use MyInfo, OneNote, and scribbled notes all over the place (the reason for wanting a better way to keep things together). This is a big reason for starting this discussion was to see what people are doing, discovering as hurdles that I can plan for and hopefully not have to deal with.
Currently, I have a post-apocalyptic campaign using the Hero System that has elements of both sci-fi and "magic" in it (think along the lines of Thundarr the Barbarian). So there are various factions, communities, and NPC that all need to stay tracked. Not to mention all the various rules that are needed for all sorts of things. I would love to see a more modern/non-fantasy generator for NPCs and settings. I've been "modernizing" fantasy settings to fit into a modern setting, which works okay, but can sometimes be a lot of work.